Radnoti Isolated Perfused Heart

The isolated perfused heart system, as originated by Oscar Langendorff more than a century ago, has become a predominant technique in pharmacological and physiological research. The technique allows the examination of cardiac contractile strength (inotropic effects), heart rate (chronotropic effects) and vascular effects without the complications of an intact animal model. From its simple beginning, the technique and equipment has evolved to include both constant pressure and constant flow models in both recirculating and non-recirculating modes. The Radnoti perfused heart system has the capacity to function in any of these configurations, allowing flexibility in experimental research and design.